Itching for Answers: Understanding PN Inside Out
Manage episode 487911797 series 3601577
Dr. Shannon Trotter sits down with Dr. Shawn Kwatra, a leading expert on chronic itch, to shed light on prurigo nodularis (PN)—a painful, often misunderstood condition frequently misdiagnosed as psychological.
Dr. Kwatra explains that PN is driven by a systemic inflammatory cycle between the immune system and nerves, creating an itch patients describe as worse than pain. He shares new insights into diagnosis, mental health impact, and cutting-edge treatments, including two FDA-approved biologics—dupilumab and nemolizumab—that offer real relief.
This episode brings awareness, compassion, and hope to those living with PN—and to the clinicians working to better treat it.
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1. Introducing Prurigo Nodularis: A Systemic Disease (00:00:00)
2. Meet Dr. Sean Quatra, Expert on Chronic Itch (00:00:56)
3. Clinical Presentation and Misdiagnosis Challenges (00:01:47)
4. The Neuroimmune Axis: How Itch Works (00:05:34)
5. Disease Associations and Diagnostic Workup (00:10:05)
6. Treatment Options: From Topicals to Biologics (00:16:36)
7. Mental Health Impact and Future Treatments (00:22:54)
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