When you hear the words Alzheimer's disease, what do you think of? The truth is, the picture most of us have of the disease is incomplete. Alzheimer's disease doesn't start when someone starts to lose their memory. It actually starts years – sometimes decades – earlier. The Rethinking Alzheimer's Disease Podcast is an engaging, narrative-style podcast miniseries for those curious or motivated to learn about Alzheimer’s disease. Perhaps you have a family member with Alzheimer’s disease, or ca ...
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محتوای ارائه شده توسط Peter Attia, MD, Peter Attia, and MD. تمام محتوای پادکست شامل قسمتها، گرافیکها و توضیحات پادکست مستقیماً توسط Peter Attia, MD, Peter Attia, and MD یا شریک پلتفرم پادکست آنها آپلود و ارائه میشوند. اگر فکر میکنید شخصی بدون اجازه شما از اثر دارای حق نسخهبرداری شما استفاده میکند، میتوانید روندی که در اینجا شرح داده شده است را دنبال کنید.https://fa.player.fm/legal
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#148 - Richard Miller, M.D., Ph.D.: The gold standard for testing longevity drugs: the Interventions Testing Program
Manage episode 284508575 series 2432666
محتوای ارائه شده توسط Peter Attia, MD, Peter Attia, and MD. تمام محتوای پادکست شامل قسمتها، گرافیکها و توضیحات پادکست مستقیماً توسط Peter Attia, MD, Peter Attia, and MD یا شریک پلتفرم پادکست آنها آپلود و ارائه میشوند. اگر فکر میکنید شخصی بدون اجازه شما از اثر دارای حق نسخهبرداری شما استفاده میکند، میتوانید روندی که در اینجا شرح داده شده است را دنبال کنید.https://fa.player.fm/legal
Richard Miller is a professor of pathology and the Director of the Center for Aging Research at the University of Michigan. He is one of the architects of the NIA-funded Interventions Testing Programs (ITPs) animal study test protocol. In this episode, Rich goes through the results of the long list of molecules tested by the ITP—including rapamycin, metformin, nicotinamide riboside, an SGLT-2 inhibitor called canagliflozin, and more. Many of the discussed outcomes have had surprising outcomes—both positive and negative findings.
…
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We discuss:
- Rich’s interest in aging, and how Hayflick’s hypothesis skewed aging research (3:45);
- Dispelling the myth that aging can’t be slowed (15:00);
- The Interventions Testing Program—A scientific framework for testing whether drugs extend lifespan in mice (29:00);
- Testing aspirin in the first ITP cohort (38:45);
- Rapamycin: results from ITP studies, dosing considerations, and what it tells us about early- vs. late-life interventions (44:45);
- Acarbose as a potential longevity agent by virtue of its ability to block peak glucose levels (1:07:15);
- Resveratrol: why it received so much attention as a longevity agent, and the takeaways from the negative results of the ITP study (1:15:45);
- The value in negative findings: ITP studies of green tea extract, methylene blue, curcumin, and more (1:24:15);
- 17α-Estradiol: lifespan effects in male mice, and sex-specific effects of different interventions (1:27:00);
- Testing ursolic acid and hydrogen sulfide: rationale and preliminary results (1:33:15);
- Canagliflozin (an SGLT2 inhibitor): exploring the impressive lifespan results in male mice (1:35:45);
- The failure of metformin: reconciling negative results of the ITP with data in human studies (1:42:30);
- Nicotinamide riboside: insights from the negative results of the ITP study (1:48:45);
- The three most important takeaways from the ITP studies (1:55:30);
- Philosophies on studying the aging process: best model organisms, when to start interventions, which questions to ask, and more (1:59:30);
- Seven reasons why pigs can't fly (2:08:00); and
- More.
419 قسمت
Manage episode 284508575 series 2432666
محتوای ارائه شده توسط Peter Attia, MD, Peter Attia, and MD. تمام محتوای پادکست شامل قسمتها، گرافیکها و توضیحات پادکست مستقیماً توسط Peter Attia, MD, Peter Attia, and MD یا شریک پلتفرم پادکست آنها آپلود و ارائه میشوند. اگر فکر میکنید شخصی بدون اجازه شما از اثر دارای حق نسخهبرداری شما استفاده میکند، میتوانید روندی که در اینجا شرح داده شده است را دنبال کنید.https://fa.player.fm/legal
Richard Miller is a professor of pathology and the Director of the Center for Aging Research at the University of Michigan. He is one of the architects of the NIA-funded Interventions Testing Programs (ITPs) animal study test protocol. In this episode, Rich goes through the results of the long list of molecules tested by the ITP—including rapamycin, metformin, nicotinamide riboside, an SGLT-2 inhibitor called canagliflozin, and more. Many of the discussed outcomes have had surprising outcomes—both positive and negative findings.
…
continue reading
We discuss:
- Rich’s interest in aging, and how Hayflick’s hypothesis skewed aging research (3:45);
- Dispelling the myth that aging can’t be slowed (15:00);
- The Interventions Testing Program—A scientific framework for testing whether drugs extend lifespan in mice (29:00);
- Testing aspirin in the first ITP cohort (38:45);
- Rapamycin: results from ITP studies, dosing considerations, and what it tells us about early- vs. late-life interventions (44:45);
- Acarbose as a potential longevity agent by virtue of its ability to block peak glucose levels (1:07:15);
- Resveratrol: why it received so much attention as a longevity agent, and the takeaways from the negative results of the ITP study (1:15:45);
- The value in negative findings: ITP studies of green tea extract, methylene blue, curcumin, and more (1:24:15);
- 17α-Estradiol: lifespan effects in male mice, and sex-specific effects of different interventions (1:27:00);
- Testing ursolic acid and hydrogen sulfide: rationale and preliminary results (1:33:15);
- Canagliflozin (an SGLT2 inhibitor): exploring the impressive lifespan results in male mice (1:35:45);
- The failure of metformin: reconciling negative results of the ITP with data in human studies (1:42:30);
- Nicotinamide riboside: insights from the negative results of the ITP study (1:48:45);
- The three most important takeaways from the ITP studies (1:55:30);
- Philosophies on studying the aging process: best model organisms, when to start interventions, which questions to ask, and more (1:59:30);
- Seven reasons why pigs can't fly (2:08:00); and
- More.
419 قسمت
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