3: Does morphine cause more nausea than hydromorphone?

Depth of Anesthesia

We investigate the claim that morphine causes more nausea than hydromorphone.

My guest is Dr. Daniel Saddawi-Konefka, program director of the Anesthesia Residency Program at Massachusetts General Hospital.

Full show notes available at depthofanesthesia.com.

Connect with us @DepthAnesthesia on Twitter or [email protected].

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Music by Stephen Campbell, MD.

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References

Felden L, Walter C, Harder S, Treede RD, Kayser H, Drover D, Geisslinger G, Lotsch J. Comparative clinical effects of hydromorphone and morphine: a meta-analysis. British Journal of Anaesthesia 2011; 107(3): 319-328

Wirz S, Wartenberg HC, Nadstawek J. Less nausea, emesis, and constipation comparing hydromorphone and morphine? A prospective open-labeled investigation on cancer pain, Support Care Cancer , 2008, vol. 16 (pg. 999-1009)

Hong D, Flood P, Diaz G. The side effects of morphine and hydromorphone patient-controlled analgesia. Anesth Analg. 2008;107:1384–9

Chang, AK, Bijur, PE, Meyer, RH, Kenny, MK, Solorzano, C, and Gallagher, EJ. Safety and efficacy of hydromorphone as an analgesic alternative to morphine in acute pain: a randomized clinical trial. Ann Emerg Med. 2006; 48: 164–172

Chang, AK, Bijur, PE, Baccelieri, A, and Gallagher, EJ. Efficacy and safety profile of a single dose of hydromorphone compared with morphine in older adults with acute, severe pain: a prospective, randomized, double-blind clinical trial. Am J Geriatr Pharmacother. 2009; 7: 1–10

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