Decoding the Origin of Cancer

The Alpha Human Podcast

In this thought-provoking episode of the Alpha Human Podcast, Lawrence presents compelling insights from the medical and scientific literature that challenge the traditional theory of cancer as a disease driven by genetic mutations, introducing evidence that underwrites alternative explanations for how cancer develops. The episode also explores the causes of Chromophobe Renal Cell Carcinoma (ChRCC), the type of cancer Lawrence has been living with for the past seven years, delving into the influence of mitochondrial dysfunction, compensatory metabolic pathways, and cell-to-cell cannibalism. Lawrence discusses significant findings from the scientific literature that could have a profound impact on ChRCC. While two of these findings were detailed in the previous episode and are particular to his case, the third explores insights from Thomas Seyfried, a renowned professor of biochemistry and genetics at Boston College that has implications for managing a broad spectrum of cancers. Lawrence also continues to share his personal journey and the importance of understanding the causes of ChRCC and cancer in general, introducing alternative hypotheses that challenge the widely accepted somatic mutation theory (SMT) of cancer. Lawrence discusses the tissue organization field theory (TOFT) as a substitute explanation for the development and progression of cancer and also explores Otto Warburg's theory of cancer as a mitochondrial metabolic disease. Lawrence cites research that supports ChRCC as a case study in line with Warburg's hypothesis, highlighting the role of mitochondrial dysfunction and the impact it has on epigenetic signaling. Furthermore, Lawrence discusses the compensatory mechanisms employed by cancer cells to survive under adverse conditions, and how Thomas Seyfried's press-pulse strategy for managing cancer exploits this adaptive response, a method that may be a powerful alternative for dealing with cancer in a nontoxic manner, and the implications it has on the unexpected way ChRCC (and a few other cancers) obtain nutrients - which may present its own unique Achille's heal (or two). Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory: www.ncbi.nlm.nih.gov/pmc/articles/PMC9138429/#B15-biomolecules-12-00662 Over a century of cancer research: Inconvenient truths and promising leads: journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.3000670 On the Origin of Cancer Cells: www.science.org/doi/10.1126/science.123.3191.309 The Prime Cause and Prevention of Cancer with two prefaces on prevention: https://t.ly/7n66a Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma: www.ncbi.nlm.nih.gov/pmc/articles/PMC6142242/ Press-pulse: a novel therapeutic strategy for the metabolic management of cancer: https://shorturl.at/fIOY4 Metabolic reprogramming and elevation of glutathione in chromophobe renal cell carcinomas: www.biorxiv.org/content/10.1101/649046v1.full Decreased Mitochondrial DNA Content Drives OXPHOS Dysregulation in Chromophobe Renal Cell Carcinoma: https://t.ly/Q33FH Endocytosis-Mediated Replenishment of Amino Acids Favors Cancer Cell Proliferation and Survival in Chromophobe Renal Cell Carcinoma: https://t.ly/i0oJL Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies: https://t.ly/eUsw9 Disclaimer: The content of this podcast, and any information, advice, opinions or statements within it are not intended, and are not to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not disregard or delay in obtaining medical advice for any medical condition you may have, and you should seek the assistance of a healthcare professional for any such conditions, and always inform your doctor of any changes you make, or are thinking about making to your lifestyle.