34. Lessons Learned From Nobel Laureates' Work, About Positive And Negative Controls (mini-series: Reading-23) Foundational Skills In Life Sciences podcast

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Crash Course DM is a comedy storytelling role play podcast set where chaos meets creativity. Join our rotating cast of improvisors as they dive into wild worlds, crazy characters, and sticky situations. Part actual play, part fever dream, all fun! Each week one of our hosts tries something new with a tabletop role playing game system and guides a cast of improvisors and comedians through the adventure. Starring: Daniel Lok, Kyle Kane, Shea Ingram, Chris Arr, and Joshua Greenway Edited by: Joshua Greenway & Daniel Lok Music by: Joshua Greenway & Mark Canning

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34. Lessons learned from Nobel Laureates' work, about positive and negative controls (mini-series: reading-23)

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محتوای ارائه شده توسط Dr. Synaptologica. تمام محتوای پادکست شامل قسمت‌ها، گرافیک‌ها و توضیحات پادکست مستقیماً توسط Dr. Synaptologica یا شریک پلتفرم پادکست آن‌ها آپلود و ارائه می‌شوند. اگر فکر می‌کنید شخصی بدون اجازه شما از اثر دارای حق نسخه‌برداری شما استفاده می‌کند، می‌توانید روندی که در اینجا شرح داده شده است را دنبال کنید.https://fa.player.fm/legal

We will complete the analysis of positive and negative controls in the milestone article of the Nobel Laureates of 2023. The article shows us one of the best examples of how to use positive and negative controls in life-science experiments. This episode will be Part 2 of a 2-part summary of control experiments. This will also conclude Step 11 of reading the article, which is to examine the key graph of the article. We can learn a lot from the Nobel Laureates!
Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.

Here are the links to the YouTube video of Nobel announcement.

Embedded on Nobel website: https://www.nobelprize.org/prizes/medicine/2023/prize-announcement/
Standalone with time stamp: https://www.youtube.com/watch?v=0JP-yDsLc3k&t=2m20s

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54 قسمت

#Science #Biology #Dr. Synaptologica #Podcasting Education #A Miniseries

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34. Lessons learned from Nobel Laureates' work, about positive and negative controls (mini-series: reading-23)

Foundational Skills in Life Sciences

published حدود یک سال پیش

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محتوای ارائه شده توسط Dr. Synaptologica. تمام محتوای پادکست شامل قسمت‌ها، گرافیک‌ها و توضیحات پادکست مستقیماً توسط Dr. Synaptologica یا شریک پلتفرم پادکست آن‌ها آپلود و ارائه می‌شوند. اگر فکر می‌کنید شخصی بدون اجازه شما از اثر دارای حق نسخه‌برداری شما استفاده می‌کند، می‌توانید روندی که در اینجا شرح داده شده است را دنبال کنید.https://fa.player.fm/legal

We will complete the analysis of positive and negative controls in the milestone article of the Nobel Laureates of 2023. The article shows us one of the best examples of how to use positive and negative controls in life-science experiments. This episode will be Part 2 of a 2-part summary of control experiments. This will also conclude Step 11 of reading the article, which is to examine the key graph of the article. We can learn a lot from the Nobel Laureates!
Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.

Here are the links to the YouTube video of Nobel announcement.

Embedded on Nobel website: https://www.nobelprize.org/prizes/medicine/2023/prize-announcement/
Standalone with time stamp: https://www.youtube.com/watch?v=0JP-yDsLc3k&t=2m20s

(My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)

… continue reading

54 قسمت

#Science #Biology #Dr. Synaptologica #Podcasting Education #A Miniseries

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Foundational Skills in Life Sciences

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54. Can you explain the role of Introduction in one sentence? 14:18

1 day پیش14:18

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The single-sentence rule for understanding research paper Introductions. Have you thought about what the Introduction section of a life-science paper really does? In this episode, we will address that question and discuss a simple rule. We will share a single sentence that encapsulates the entire role of the Introduction. It will make it easy to grasp the authors' intention and the paper’s core logic. Hint: it is related to the key trio in the Abstract: the "Background-Known-Unknown" trio from Episode #53. This episode = mini-series: reading-34. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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53. Minimum features of well-written abstracts 16:20

۹ روز پیش16:20

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In today’s episode, we will learn which structural components will be minimally essential for an abstract, and which will be additionally necessary for a well-written abstract. These are the abstracts of primary research papers in life sciences, both in clinical- and basic-science fields. There are very many variations in the structures of published abstracts. Why do we want to discuss the above topic? This is because understanding the essential components of abstracts will help us anticipate key information and understand the content more effectively! This episode = mini-series: reading-33. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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52. Example of a well-written abstract (other than the one by Nobel Laureates) 19:57

۶ weeks پیش19:57

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Let’s talk about an excellent abstract that I read this week. It was so well written, and I was so excited to read it that I wanted to talk about it with you today. The beauty of it is that the first 3 structural components guide us through the authors’ intention and question very clearly. But there was also a little twist to the structure: we will talk about it, too. The abstract that we talked about today was from the following paper: “A meta-analysis of technology use and cognitive aging” Benge & Scullin, Nature Human Behaviour, 2025 “Online ahead of print” (thus, no volume number or page numbers) as of the date of this episode upload. PubMed link: https://pubmed.ncbi.nlm.nih.gov/40229575/ Journal link: https://doi.org/10.1038/s41562-025-02159-9 We can read its abstract on either of the above websites. Unfortunately, the other parts of the paper are subscription-based. So, they are accessible, if you or your institutions have a subscription to the journal. This episode = mini-series: reading-32. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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51. Have you read an abstract that was not written well? 8:55

۸ weeks پیش8:55

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8:55

My students selected a paper to read in a journal club. The abstract (and the rest of the paper) was not written well. The abstract gave us two precious lessons. Lesson 1: Good structural organization will help the readers understand the content. Lesson 2: Abstracts of peer-reviewed papers can be disorganized. I hope you learn them in this episode, too! This episode = mini-series: reading-31. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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50. Happy 50th episode! 5:39

10 weeks پیش5:39

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We have reached 50 episodes! Thank you for listening. Today, we will briefly talk about how I have kept sustainable podcasting so far. The most important thing may be that I have set my goal simple and single: It is to create high-quality content for you. That’s it. Here are links to two sources of podcast statistics that I mentioned in the episode. https://www.amplifimedia.com/blogstein-1/lyspqop3ylro9a2t7y2de820uwkgwx https://podcastindex.org/stats (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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49. Another well-crafted logic loop in Abstract by Nobel Laureates (mini-series: reading-30) 18:26

11 weeks پیش18:26

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18:26

We will talk about the second of the two, well-crafted loops of logic, in the Abstract of a paper written by the Nobel Prize Laureates. Not all abstracts have this second loop. But when it is present, it gives a better overview of the impact of the presented work. We can find one of the best examples in our Abstract. We are reading the paper written by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman, that led to the Nobel Prize in Physiology or Medicine 2023. We call it the Milestone Article 1. Here are two sets of links related to the paper. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user For finding our Milestone Articles 1, 2 and 3 (i.e., three papers written by the Laureates that led to the Nobel Prize), visit the following website that shows the “Press Release” of the Nobel Prize in Physiology or Medicine 2023. Look for "Key publications" section. https://www.nobelprize.org/prizes/medicine/2023/press-release/ We discussed how to find Milestone Articles 1~3 as above, in Episode #10. Here is the link to the episode: https://synaptologica.buzzsprout.com/2219599/episodes/14122755 (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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48. Well-crafted logic loop in Abstract by Nobel Laureates (mini-series: reading-29) 19:32

13 weeks پیش19:32

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19:32

I can visualize two well-crafted loops of logic, in the Abstract of a paper written by the Nobel Prize Laureates. Can you? We will talk about one of them in today’s episode. Such a loop, together with a linear progression, highlights the authors’ clear and logical thought process. We are reading the paper written by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman, that led to the Nobel Prize in Physiology or Medicine 2023. We call it the Milestone Article 1. Here are two sets of links related to the paper. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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47. Why is the 2nd sentence important in an abstract? (mini-series: reading-28) 20:32

13 weeks پیش20:32

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20:32

Let's analyze a single sentence in the Abstract of an impressive paper. It is the paper that led to the 2023 Nobel Prize in Physiology or Medicine. This is the paper that we call the milestone article 1 (Please see below for details). We will analyze the second sentence. Why is this sentence important? We will discuss four of my approaches to see that this sentence is important, beautiful and helpful for readers outside the field. It is fun to spend one episode for just a single sentence, and think deep about how it reveals the authors' logic. Here are two sets of links related to the paper written by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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46. Let’s analyze the Abstract of a paper written by Nobel Laureates (mini-series: reading-27) 27:59

15 weeks پیش27:59

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27:59

Today, we will analyze the Abstract of an impressive paper. It is the paper that led to the 2023 Nobel Prize in Physiology or Medicine. This is the paper that we call the milestone article 1. We will have two essential pre-analysis sub-steps, and then we will analyze each sentence. During this analysis, we will read each sentence of the Abstract, examine the role of each sentence, and assign each sentence to a structural component, so that we will be able to understand the authors’ intention for each sentence. Here are two sets of links mentioned in this episode. All are related to the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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45. Let’s read the Abstract of a paper written by Nobel Laureates (mini-series: reading-26) 20:34

17 weeks پیش20:34

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20:34

Today, we will take a significant step towards understanding the 2023 Nobel Prize in Physiology or Medicine. We will read the Abstract of the Laureates’ most important paper that led to the Nobel Prize. This is the paper that we call the milestone article 1. We will have two essential pre-reading sub-steps, and then we will conduct the initial readings. These sub-steps will set the stage for a more in-depth exploration in the next episode. Here are two sets of links mentioned in this episode. All are related to the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. YouTube video of Nobel announcement (starting at ~2 minutes and 20 seconds) Embedded in Nobel website: https://www.nobelprize.org/prizes/medicine/2023/prize-announcement/ Standalone with time stamp: https://www.youtube.com/watch?v=0JP-yDsLc3k&t=2m20s Milestone Article 1: Immunity, 2005 DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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44. An evolving reader: my phases through reading textbooks (Q&A-5: textbooks, part 2) 22:12

20 weeks پیش22:12

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22:12

How are you reading life-science textbooks? My approach to reading textbooks has evolved significantly throughout my academic career, from student to researcher to instructor to course director. Today’s episode is part 2. We will discuss the last two phases of my experience. I am now in the fourth phase. I fully appreciate how well the authors summarized a vast amount of knowledge in one field of life sciences, in coherent and consistent manners. Please enjoy listening to my different phases of reading textbooks. It will be great if these episodes serve in stimulating your thoughts about how to read textbooks. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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43. An evolving reader: my phases through reading textbooks (Q&A-5: textbooks, part 1) 22:13

23 weeks پیش22:13

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22:13

How are you reading life-science textbooks? My approach to reading textbooks has evolved significantly throughout my academic career, from student to researcher to instructor to course director. Today’s episode is part 1. We will discuss the first two phases of my experience. My overall goal of the two-part episodes is to highlight the unique roles that textbooks play, different from those of primary research papers. Knowing these different purposes will help us read textbooks more effectively. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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42. Happy Holidays! 1:01

24 weeks پیش1:01

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1:01

Happy Holidays to you, and I wish you the very best in 2025!

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41. Exclude or include seemingly irrelevant experiences in your academic CV? (Q&A-4: CV) 22:01

29 weeks پیش22:01

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22:01

“Should I exclude irrelevant experiences from my academic CV?” This is a question that students often ask. In this episode, I would like to give you my thoughts about this question. In general, there is a way of creating a comprehensive CV: it will show that you have unique experiences, and you are a careful and a thoughtful writer. The key would be for you to be proud of what you did in the past. I hope that this discussion will be useful for you. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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40. Short or long CV for applying for a research position? (Q&A-3: CV) 16:23

32 weeks پیش16:23

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16:23

“Should my CV be short or long, when I apply for a research assistant position in a college/university lab?” This is a question that students often ask. In this episode, I would like to give you my thoughts about this question. The content in a CV depends on the person’s career stage. But I have one common viewpoint for CVs at all stages. I would like to view the descriptions in the CV, during and after the undergraduate education, as the defining statements of the person. My thoughts about today’s question will be related to this viewpoint. At the same time, I agree that different professors and different students may have opinions different from mine. Let’s discuss them and share diverse perspectives, so that our thoughts will become deeper. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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39. Eight key components define the Abstract structure (mini-series: reading-25) 18:57

33 weeks پیش18:57

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18:57

How do top-tier scientific journals, like Nature, make sure their abstracts are clear and impactful? In today’s episode, we will identify the eight key components that make those abstracts effective, by naming the components in our own words, and clarifying their roles and order. Our system was inspired by the Nature document for the Abstract guidelines that we discussed in the Episode #38. Here is the URL that brings you directly to the Nature document: https://www.nature.com/documents/nature-summary-paragraph.pdf (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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38. The journal, Nature, dissects the Abstract structure (mini-series: reading-24) 13:26

35 weeks پیش13:26

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13:26

What is the best way to learn how to read the Abstract of a scientific paper? In my view, the best way is to learn how the Abstract is structured in any paper. Today, we will learn it, by reading a very short document. It is a one-page document that describes the Abstract guidelines, provided by the journal, Nature. Here is the URL that brings you directly to the Nature document: https://www.nature.com/documents/nature-summary-paragraph.pdf Here is the URL of the webpage for the Instructions for Authors by Nature. The above document can be found as the hyperlink to the note, “annotated example” in the “Articles” section: https://www.nature.com/nature/for-authors/formatting-guide Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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37. Announcement of The Nobel Prize in Chemistry 2024, relevant to life scientists! 9:23

36 weeks پیش9:23

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9:23

The 2024 Nobel Prize was announced! Two days ago, it was in Physiology or Medicine. Yesterday, it was in Physics. Today, it was in Chemistry. The Nobel Prize in Chemistry was awarded to Dr. David Baker “for computational protein design”, and to Dr. Demis Hassabis and Dr. John Jumper, “for protein structure prediction.” Their work is directly related to life sciences. Let’s learn about the work by watching a YouTube video. It is the archived video of the announcement of The Nobel Prize. I am sure you enjoy listening to podcasts. I am also happy to report to you that Dr. David Baker launched “The Baker Lab Podcast” just two weeks before this recording! Here is the URL of the YouTube video: https://www.youtube.com/watch?v=bPjB9NRu8Jc Here is the URL of the same video, but with a timestamp at the start of slide presentation: https://www.youtube.com/watch?v=bPjB9NRu8Jc&t=4m40s Here is the URL of the same video, but embedded on the Nobel Prize website: https://www.nobelprize.org/prizes/chemistry/2024/prize-announcement/ Here is the URL of a new podcast, “The Baker Lab Podcast” hosted by Dr. David Baker: https://www.bakerlab.org/podcast/ Enjoy the video and the podcast! (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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36. Announcement of The Nobel Prize in Physics 2024, relevant to life scientists! 8:25

36 weeks پیش8:25

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8:25

The 2024 Nobel Prize was announced! Yesterday, it was in Physiology or Medicine. Today it was in Physics. It was awarded to Dr. John Hopfield, and Dr. Geoffrey Hinton, “for foundational discoveries and inventions that enable machine learning with artificial neural networks.” It is somewhat (indirectly) related to my field, neuroscience! Let’s learn about the work by watching a YouTube video. It is the archived video of the announcement of The Nobel Prize. Here is the URL of the YouTube video: https://www.youtube.com/watch?v=SBGG4WNweEc Here is the URL of the same video, but embedded on the Nobel Prize website: https://www.nobelprize.org/prizes/physics/2024/prize-announcement/ Enjoy the video! (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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Foundational Skills in Life Sciences

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35. Announcement of The Nobel Prize in Physiology or Medicine 2024 3:19

36 weeks پیش3:19

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3:19

The 2024 Nobel Prize was announced! This year’s Nobel Prize in Physiology or Medicine was awarded to Dr. Victor Ambros, and Dr. Gary Ruvkun, “for the discovery of microRNA and its role in post-transcriptional gene regulation.” Let’s learn about the work by watching a YouTube video. It is the archived video of the announcement of The Nobel Prize. Here is the URL of the YouTube video: https://www.youtube.com/watch?v=Ln5rCmDqua0 Here is the URL of the same video, but embedded on the Nobel Prize website: https://www.nobelprize.org/prizes/medicine/2024/prize-announcement/ Enjoy the video! (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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Foundational Skills in Life Sciences

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34. Lessons learned from Nobel Laureates' work, about positive and negative controls (mini-series: reading-23) 31:10

39 weeks پیش31:10

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31:10

We will complete the analysis of positive and negative controls in the milestone article of the Nobel Laureates of 2023. The article shows us one of the best examples of how to use positive and negative controls in life-science experiments. This episode will be Part 2 of a 2-part summary of control experiments. This will also conclude Step 11 of reading the article, which is to examine the key graph of the article. We can learn a lot from the Nobel Laureates! Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Here are the links to the YouTube video of Nobel announcement. Embedded on Nobel website: https://www.nobelprize.org/prizes/medicine/2023/prize-announcement/ Standalone with time stamp: https://www.youtube.com/watch?v=0JP-yDsLc3k&t=2m20s (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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Foundational Skills in Life Sciences

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33. How to do a good oral presentation? Hidden, but important tip (Q&A-2: presentation) 17:44

40 weeks پیش17:44

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17:44

Question of today: What is a practical tip for effective oral presentations? There are many important things to do, for delivering oral presentations successfully. But I will be happy to give you my number one tip and the reasons why. And this tip is not discussed often in scientific communities. I hope you will find it useful! Disclaimer: What I'm going to tell you is my personal opinion. It is possible that it does not apply to you in your own specific situation, in your program, in your own institution, and in your country. And each professor could have a different opinion. So, please listen to my comment, not as definitive advice, but just as a reference. I hope my comment will still serve you as a starting point for your thought. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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Foundational Skills in Life Sciences

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32. Is it important to include positive and negative controls in each experiment? Lesson from Nobel Laureates' work (mini-series: reading-22) 21:32

42 weeks پیش21:32

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21:32

We will examine the positive and negative controls in the milestone article of the Nobel Laureates. The article shows us one of the best examples of how to use positive and negative controls in life-science experiments. We will compare a total of eight figure panels. And we will learn important lessons from them, for designing experiments and for reading figures. This episode will be Part 1 of a summary of control experiments. Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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31. Is it OK to say, “I don’t know” in response to technical questions? (Q&A-1: interview) 12:02

43 weeks پیش12:02

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12:02

The first Q&A session! Question of today: Is it OK to say, “I don’t know” in response to technical questions in an interview when you apply for a life-science research position in a laboratory? I will give you my answer and the reasons why. Disclaimer: What I'm going to tell you is my personal opinion. It is possible that it does not apply to you in your own specific situation, in your program, in your own institution, and in your country. And each professor could have a different opinion. So, please listen to my comment, not as definitive advice, but just as a reference. I hope my comment will still serve you as a starting point for your thought. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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30. Positive controls in another experiment by Nobel Laureates (mini-series: reading-21) 32:41

43 weeks پیش32:41

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32:41

We will keep analyzing the specific positive controls that the Nobel Laureates used in their milestone article 1 that led to the Nobel Prize. We will examine the four positive controls in the third figure of this paper, and in other figures as well. Those positive controls did not necessarily show positive responses in multiple figures. We will observe that positive controls can show variable behaviors in a paper. We will also discuss how a modified definition of positive controls will be helpful for understanding them. Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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29. Positive controls in experiments by Nobel Laureates (mini-series: reading-20) 25:31

45 weeks پیش25:31

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25:31

Let’s analyze the specific positive controls that the Nobel Laureates used in their milestone article 1 that led to the Nobel Prize. We will look at the first two figures and four positive controls therein. As always, we are impressed by the meticulous design of the experiments by the Laureates. Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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28. Defining positive controls in life-science experiments (mini-series: reading-19) 13:11

46 weeks پیش13:11

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13:11

In this episode, we shift our focus from negative controls to their counterparts: positive controls. We will begin by defining what we mean by positive controls. Then we will refine that definition to encourage practical and cautious thinking. Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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27. One-year anniversary: I started podcasting to help you (podcast update 5) 21:02

47 weeks پیش21:02

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21:02

One-year anniversary of this podcast channel! Thank you for listening. Why did I start podcasting? The motivation or the trigger was the students’ feedback to my teaching and training: they loved it. My goal is to help you learn and polish your skills in life sciences. In this episode, I will talk about a little story of how I started podcasting. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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26. Lessons learned from a failed experiment. Part 2 (mini-series: reading-18) 34:47

48 weeks پیش34:47

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34:47

This episode continues from the last one. This will mark the end of our story about the life-science experiment that did not work at first, but worked well after extensive troubleshooting. We will talk about the remaining three lessons we can learn from the story. They will be about thoughtful approaches, and about probably the most important mindset in life sciences (What will it be?). This is Part 18 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active: ideas@synaptologica.com. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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25. Lessons learned from a failed experiment. Part 1 (mini-series: reading-17) 31:30

49 weeks پیش31:30

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31:30

In the last episode, we finished discussing details of the life-science experiments in our story. We observed that negative controls can be powerful tools for troubleshooting and ensuring data quality. The story gave us invaluable learning experience. What lessons can we learn? We will talk about three lessons related to negative controls today. They will help us design good research and evaluate results well. This is Part 17 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active: ideas@synaptologica.com. But my website is under construction. Please wait for a while. Thank you for the patience!)…

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