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Richard Lu: OPCs and Oligodendrocytes – Roles in Brain Development, Function, and Cancer
Manage episode 442988611 series 3558288
محتوای ارائه شده توسط Mark Mattson. تمام محتوای پادکست شامل قسمت‌ها، گرافیک‌ها و توضیحات پادکست مستقیماً توسط Mark Mattson یا شریک پلتفرم پادکست آن‌ها آپلود و ارائه می‌شوند. اگر فکر می‌کنید شخصی بدون اجازه شما از اثر دارای حق نسخه‌برداری شما استفاده می‌کند، می‌توانید روندی که در اینجا شرح داده شده است را دنبال کنید.https://fa.player.fm/legal
In this episode Richard Lu – a professor of pediatrics at the University of Cincinnati Chldren’s Hospital talks about a type of stem cell in the brain called oligodendrocyte progenitor cells (OPC). OPC normally differentiate into the oligodendrocytes that wrap around the axons of neurons providing insulation that greatly speeds up the propagation of electrical impulses. These cells also provide nutrients to neurons and produce proteins that promote the survival of the neurons. But OPC can and unfortunately do become transformed into cancer cells. Dr. Lu talks about the normal roles of OPC in brain development and how they can form brain tumors.
LINKS:
Dr. Lu’s laboratory web page:
https://www.cincinnatichildrens.org/research/divisions/e/ex-hem/labs/lu
Oligodendrocytes – review
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8018611/pdf/nihms-1686441.pdf
Oligodendrocytes – Brain repair and cancers
https://www.sciencedirect.com/science/article/pii/S0969996120303156?via%3Dihub
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