Paul Kohlhaas & Tyler Golato: VitaDAO – The Collective Funding Longevity Research

Epicenter - Learn about Crypto, Blockchain, Ethereum, Bitcoin and Distributed Technologies

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All About Change

1
Tiffany Yu — Smashing Stereotypes and Building a Disability-Inclusive World 30:23

12 روز پیش30:23

پخش در آینده

لیست ها

پسندیدن

دوست داشته شد

30:23

Tiffany Yu is the CEO & Founder of Diversability, an award-winning social enterprise to elevate disability pride; the Founder of the Awesome Foundation Disability Chapter, a monthly micro-grant that has awarded $92.5k to 93 disability projects in 11 countries; and the author of The Anti-Ableist Manifesto: Smashing Stereotypes, Forging Change, and Building a Disability-Inclusive World. As a person with visible and invisible disabilities stemming from a car crash, Tiffany has built a career on disability solidarity. Now that she has found success, she works to expand a network of people with disabilities and their allies to decrease stigmas around disability and create opportunities for disabled people in America. Episode Chapters 0:00 Intro 1:26 When do we choose to share our disability stories? 4:12 Jay’s disability story 8:35 Visible and invisible disabilities 13:10 What does an ally to the disability community look like? 16:34 NoBodyIsDisposable and 14(c) 21:26 How does Tiffany’s investment banking background shape her advocacy? 27:47 Goodbye and outro For video episodes, watch on www.youtube.com/@therudermanfamilyfoundation Stay in touch: X: @JayRuderman | @RudermanFdn LinkedIn: Jay Ruderman | Ruderman Family Foundation Instagram: All About Change Podcast | Ruderman Family Foundation To learn more about the podcast, visit https://allaboutchangepodcast.com/…

۴ سال پیش 1:27:50

MP3•خانه قسمت

VitaDAO is a decentralized collective funding early stage longevity research. Their mission is to extend human lifespan by researching, financing, and commercializing longevity therapeutics in an open and democratic manner.

We were joined by Tyler Golato and Paul Kohlhaas, co-founders of Molecule and initiators of VitaDAO to talk about how drug discovery and approval currently works, what the status of longevity research is, what role IP plays -- and how all of this could change in the future with DAOs like VitaDAO.

Topics covered in this episode:

Paul and Tyler's backgrounds and how they came to work on VitaDAO
Longevity - thinking of aging as a disease
Where is the research at today?
How longevity research currently takes place in the pharmaceutical industry
How VitaDAO is alleviating patency issues
The first funded project with the Knudsen lab in Copenhagen - Molecule
How DAOs make the decisions

Episode links:

Sponsors:

Chorus One: Chorus One runs validators on cutting edge Proof of Stake networks such as Cosmos, Solana, Celo, Polkadot and Oasis. - https://epicenter.rocks/chorusone
ParaSwap: ParaSwap aggregates all major DEXs and makes sure you beat the market price at every single swap and with the lowest slippage - http://paraswap.io/epicenter - paraswap.io/epicenter

This episode is hosted by Friederike Ernst & Meher Roy. Show notes and listening options: epicenter.tv/403

611 قسمت

Paul Kohlhaas & Tyler Golato: VitaDAO – The Collective Funding Longevity Research

Epicenter - Learn about Crypto, Blockchain, Ethereum, Bitcoin and Distributed Technologies

56 subscribers

published ۴ سال پیش

اشتراک گذاری

MP3•خانه قسمت

Topics covered in this episode:

Paul and Tyler's backgrounds and how they came to work on VitaDAO
Longevity - thinking of aging as a disease
Where is the research at today?
How longevity research currently takes place in the pharmaceutical industry
How VitaDAO is alleviating patency issues
The first funded project with the Knudsen lab in Copenhagen - Molecule
How DAOs make the decisions

Episode links:

Sponsors:

Chorus One: Chorus One runs validators on cutting edge Proof of Stake networks such as Cosmos, Solana, Celo, Polkadot and Oasis. - https://epicenter.rocks/chorusone
ParaSwap: ParaSwap aggregates all major DEXs and makes sure you beat the market price at every single swap and with the lowest slippage - http://paraswap.io/epicenter - paraswap.io/epicenter

This episode is hosted by Friederike Ernst & Meher Roy. Show notes and listening options: epicenter.tv/403

611 قسمت

همه قسمت ها

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Stripe: The Stablecoin (R)Evolution - John Egan 1:05:36

۳ روز پیش1:05:36

1:05:36

Stripe has established itself as a leading payment solution for both enterprises as well as startups and individual sellers. By abstracting away all the complexities of traditional payment rails through simple plug-and-play APIs, Stripe created a facile route for cross-border payments, simplifying e-commerce. Similarly, Stripe’s recent integration of stablecoins could further bolster the adoption of decentralised payment solutions, be them USD or other currency proxies. This allows businesses to reach more markets, at a lower cost, with near-instantaneous settlement. Topics covered in this episode: John’s background Stripe’s mission How Stripe solves the complexity of internet payments Integrating crypto for payments Supported blockchains Stripe’s Web3 services Upsides of accepting stablecoin payments Non-USD stablecoins Merchant UX Expanding crypto support outside the U.S. On- and off-ramping Acquiring Bridge and Privy The best of both worlds: CeFi & DeFi Episode links: John Egan on X Stripe on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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t1 Protocol: Unifying Ethereum's L2 Liquidity Through Real-Time Proving - Can Kisagun 1:01:41

۷ روز پیش1:01:41

1:01:41

While L2 rollups did help scale Ethereum, they also created siloed ecosystems, all fighting over the same liquidity, users and devs. t1 Protocol is building layer-2 infrastructure to achieve seamless cross-rollup interoperability through real-time proving, powered by TEEs. t1's low-latency with 1-second block times provides faster preconfirmations, significantly improving UX, all while maintaining full Ethereum composability. Topics covered in this episode: Can’s background Why Enigma/Secret Network built on Cosmos Solving Ethereum’s liquidity fragmentation t1’s rollup & real-time proving in TEEs Sequencer setup inside the TEE Dealing with other rollup trust assumptions Integrating new L2s Permissionless TEEs Potential attack vectors TEE alternatives Asset issuance on mainnet vs. L2s t1 development Partnerships & BD Solana vs. Ethereum UX TEE misconceptions Episode links: Can Kisagun on X t1 Protocol on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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DappCon 25: The Ticker Is $ETH - Jerome de Tychey, Joshua Dávila & Nixorokish 1:12:32

14 روز پیش1:12:32

1:12:32

As the summer tour of European crypto conferences landed in Berlin, one of crypto’s cradles, we couldn’t miss DappCon 25, where we got to sit with Jerome de Tychey, Nixorokish & Joshua Dávila to discuss Ethereum’s restructure and whether its culture is still relevant to the wider crypto community. Join us for a fascinating discussion on the impact of crypto politicization and how Ethereum’s ecosystem evolved amidst a society with ever-changing values. Topics covered in this episode: Jerome, Nixorokish & Josh backgrounds Ethereum Foundation restructuring Ethereum’s culture & crypto politicization DAOs & the evolution of Ethereum’s ecosystem Is privacy still a societal value? User experience & account abstraction Future hopes for Ethereum Episode links: Jerome de Tychey on X Nixorokish on X Joshua Davila on X DappCon on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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Lombard: Unlocking Bitcoin DeFi Through Liquid, Yield-Bearing LBTC - Jacob Phillips 1:11:09

18 روز پیش1:11:09

1:11:09

Bitcoin remains an untapped source of net-new liquidity that could be injected into DeFi. This would completely reshape Bitcoin’s utilization from a mere store of value to a liquid asset that can be ported cross-chain and traded like a liquid staking derivative. Lombard’s LBTC builds upon Babylon’s Bitcoin staking primitive and aims to unlock new yield sources for the industry’s leading asset by increasing its DeFi utilization. Topics covered in this episode: Jacob’s background Lessons gathered from Polychain Focusing on Bitcoin Why Bitcoin staking is crucial for BTC DeFi Building on top of Babylon LBTC minting Sources of BTC yield PoS inflation and native token incentives BTC as a trading pair in DeFi Lombard chain Future challenges to overcome Bitcoin L2s Lombard milestones Episode links: Jacob Phillips on X Lombard on X Babylon on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain.…

1
Staking Rewards: Is Crypto Staking Killing Decentralisation? - Mirko Schmiedl & Tobias Jung 54:55

28 روز پیش54:55

54:55

Apart from incentivising market participants to secure the network through inflationary rewards, many consider staking as an equivalent of stock dividend yield. As a result, although Bitcoin is regarded as digital gold, protocols are looking for ways to increase its utilisation in DeFi and, ultimately, generate yield. Nowadays, while newer networks are struggling to attract investors and sustain a healthy, decentralised validator set, more established blockchains capture the lion’s share of PoS actors. However, in a constant race for profit basis points, centralised consolidation of stakers seems inevitable. Join us for a fascinating discussion on the staking landscape and the challenges it may present to decentralisation. Topics covered in this episode: Increasing BTC utilization through BTC yield Looping yield products The maturation of the staking market Chorus One staking portfolio How to prevent staking consolidation Retail vs. institutional-grade operators Symbiotic, Eigenlayer & restaking yield Episode links: Mirko Schmiedl on X Tobias Jung on X Staking Rewards on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain & Sebastien Couture.…

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ETHPrague: ETH Renaissance - Austin Griffith, Brenda Loya, Joseph Schweitzer, Marek Olszewski 1:00:25

۵ weeks پیش1:00:25

1:00:25

After a decade of existence, Ethereum has gone a long way from its initial whitepaper, yet many efforts in scaling and finding product-market-fit have been severely criticized for falling short of their promise. However, despite numerous other ‘Ethereum killers’ being launched over the years, none has managed to attract so many developers and liquidity while sticking true to ethos that (once) powered and united this industry. This year’s ETHPrague plans to confront exactly these existential challenges and steward community culture towards addressing outside criticism and external reality checks. Ethereum’s development, while adapting to market pressures, it always aimed to stick true to its core values in order to remain a technological bedrock for the future of humanity. Topics covered in this episode: The vision for ETH Prague Takeaways from main sessions High-level overview of ETH Prague The resurgence of Polkadot European crypto summer events The general state of the Ethereum ecosystem Celo’s transition to L2 L2 liquidity fragmentation Choosing the right L2 to build Improving hackathons Lightning round Final words Episode links: Austin Griffith on X Marek Olszewski on X Brenda Loya on X Joseph Schweitzer on X BuidlGuidl DAO on X Celo on X Tellor on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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۶ weeks پیش31:52

31:52

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Initia: Incentively Aligned Appchains - Ezaan Mangalji, Anil Lulla & Jose Maria Macedo 1:02:08

۷ weeks پیش1:02:08

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Blockchain architecture is constantly being forced to adapt to new technologies, as well as to meet new demands from users and builders. While the idea of apps building their own chains was first explored by Cosmos, it lacked the support and tooling to see it succeed. Later on, rollups also took the centerstage of Ethereum’s scaling roadmap, but due to their general purpose design, it led to a cannibalistic ecosystem. Initia learned from these 2 models and combined the best of both worlds: it built a full-stack framework for a seamless DevEx from the get-go and, more importantly, it designed its tokenomics in order to ensure maximum incentive alignment for its appchains. While the former decision removed the need for each separate chain to reinvent the wheel and risk ending up ‘a jack of all trades, master of none’, the latter ensured that appchains would not extract value away from the L1. Topics covered in this episode: Ezaan’s background From building on Terra to Initia How Initia is rewriting the appchain thesis Initia’s enshrined liquidity & vested interest program (VIP) Metrics & Initia’s bet on crypto innovation Solving liquidity fragmentation Delphi’s involvement in Initia Future roadmap Episode links: Ezaan Mangalji on X Jose Maria Macedo on X Anil Lulla on X Initia on X Delphi Digital on X Delphi report on Initia Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain.…

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Ethereum Foundation: Humanity’s Shared World Computer - Hsiao-Wei Wang & Tomasz Stańczak 1:10:21

۸ weeks پیش1:10:21

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As society evolves, so do its values and principles, but is that desirable for technology that seeks to build the most reliable, trustless and censorship resistant global settlement layer? Ever since the rise in popularity of Solana with its inflow of retail capital in a memecoin gold rush, Ethereum became even more criticized for sticking true to its core values despite the completely divergent demands of market participants. Moreover, the rollup centric scaling roadmap seemed to further silo attention and cause liquidity fragmentation, driving away value from Ethereum mainnet. As institutional demand is expected to grow with the introduction of staking ETFs, a new executive leadership took charge of Ethereum foundation to help steer the protocol’s narrative at the intersection between community demands and Ethereum’s ethos. Topics covered in this episode: Hsiao-Wei’s & Tomasz’ backgrounds How they became co-executive directors of Ethereum Foundation Ethereum Foundation’s role moving forward Decision making in Ethereum Foundation Shaping Ethereum’s narrative The layer 2 landscape Scaling Ethereum as the global settlement layer Sharding Rollup scalability & their trade-offs What values drive adoption L2 interoperability Future goals Episode links: Hsiao-Wei Wang on X Tomasz Stanczak on X Ethereum Foundation on X Ethereum on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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۸ weeks پیش1:08:05

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۹ weeks پیش1:03:09

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10 weeks پیش54:49

54:49

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11 weeks پیش1:01:21

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Tally is a software platform designed to support tokenized organizations, particularly Decentralized Autonomous Organizations (DAOs) and crypto communities. It provides tools for launching tokens, governing protocols, and enabling staking to foster community participation and growth. Tally facilitates onchain governance, allowing transparent and decentralized decision-making for managing funds, grants, and protocol upgrades. It powers major blockchain ecosystems like Arbitrum, ZKsync, Uniswap DAO and Wormhole DAO by providing interfaces for proposal creation, voting, and staking. The Tally Protocol further enhances this by offering a liquidity layer for governance tokens, that allow token holders to earn staking rewards while retaining voting rights and participating in DeFi. Topics covered in this episode: Dennison’s background Has crypto won? Does privacy still matter? The vision behind Tally The evolution of DAOs Are grassroots DAOs viable? Corporate vs. DAO PMF How developer activity & contributors evolved Tally’s roadmap ICO vs. IPO Episode links: Dennison Bertram on X Tally on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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12 weeks پیش48:42

48:42

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1
Lido V3: Ushering in Institutional Staking Through stVaults - Hasu 1:19:32

13 weeks پیش1:19:32

1:19:32

Ethereum’s transition from proof-of-work to proof-of-stake created a unique set of conditions (i.e. lack of protocol-level delegation, 32 ETH requirement, long exit queues, etc.) that led to Lido’s liquid staking model to gain huge traction, significantly eclipsing other LSD providers on native PoS chains. stETH added on-demand liquidity, bypassing withdrawal windows, while also increasing DeFi utilization and increasing yields. Moreover, by allowing users to stake any amount of ETH in pools, it removed the requirement for 32 ETH increments, ultimately improving decentralisation through long tail distribution of individual stakers. Lido V3 introduces modular stVaults which enable staking customization. This allows professional actors, such as institutional stakers, to have granular control over validators, MEV and other parameters, diversifying their investment strategies. Topics covered in this episode: Hasu’s background Discovering Lido Liquid staking and the early days of Lido Why liquid staking gained traction on Ethereum The evolution of Lido Initial decentralisation concerns and the importance of dual governance Restaking Lido V3 and vaults Institutional staking & ETFs Ethereum’s ‘crisis’ and its values Episode links: Hasu on X Lido on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain.…

Epicenter - Learn about Crypto, Blockchain, Ethereum, Bitcoin and Distributed Technologies

1
Ronin: How Axie Infinity Kickstarted the Blockchain Gaming Revolution - Jeff Zirlin 54:34

14 weeks پیش54:34

54:34

While DeFi’s ultimate goal is to provide an alternative for TradFi, blockchain gaming caters to retail masses, onboarding millions of users to crypto through incentives and fun gameplay. The greatest success story in Web3 gaming thus far has been, without a doubt, Axie Infinity. Apart from creating an engaged community whose early adopters also experienced rags-to-riches stories, it kickstarted an entire movement around play-to-earn gaming. Many have tried copying it, yet most of them failed. Axie Infinity managed to design a sustainable economy that combined NFTs and fungible tokens. The result was the first gamified crypto mining event, at scale. In order to accommodate such a massive demand, in a time when L2 rollups were still in R&D, Sky Mavis founded Ronin, a gaming-oriented Ethereum sidechain. The community that formed around Axie Infinity created a tremendous network effect, solidifying Ronin’s PMF as a gaming powerhouse. Before long, many up-and-coming titles migrated to Ronin, and the growth effects in all their key metrics (i.e. DAUs, transactions, revenue, etc.) further fuelled the flywheel. Topics covered in this episode: Jeff’s background Cryptokitties Joining Axie Infinity and how it evolved Monetizing Axie’s economy The recipe for successful blockchain games Building Ronin, the gaming L1 On-chain vs. off-chain game elements Community building Ronin’s economy & composability Most suitable gaming genre for Web3 AI x gaming Crypto gaming investments Ronin’s current state and future roadmap Axie’s upcoming MMO Episode links: Jeff Zirlin on X Axie Infinity on X Ronin on X Sky Mavis on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain.…

Epicenter - Learn about Crypto, Blockchain, Ethereum, Bitcoin and Distributed Technologies

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Solana: From On-Chain Nasdaq to the Pump Fun Craze - Anatoly Yakovenko 1:18:28

16 weeks پیش1:18:28

1:18:28

Solana needs no introduction. Ever since its inception, it pushed throughput scaling on a single chain, without the need of sharding or rollups. Despite its ups and downs that culminated at the bottom of the bear market after the FTX crash, it managed to not only survive, but build a vibrant community around crypto's (arguably) most prominent PMF (thus far). Join us for a fascinating discussion and learn about Anatoly's take on controversial topics such as MEV, concurrent block leaders (the equivalent of Ethereum's PBS proposal), L2 rollups, Solana economics, how to tackle potential exploits and more. Topics covered in this episode: How the original Solana vision turned out What makes blockchains valuable MEV & program writable accounts Concurrent block proposers Current bottlenecks for scaling Solana Mainnet vs. L2 rollups Firedancer upgrade Halting the network vs. rollbacks Solana’s scaling roadmap DoubleZero Worst hacks on Solana UI exploits, Bybit hack and smart contract security Solana economics and the SIMD-0228 proposal Future improvements Use cases for blockchains Solana mobile Episode links: Anatoly Yakovenko on X Solana on X Solana Mobile on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain & Martin Köppelmann.…

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1
Build on Bitcoin: Combining Bitcoin's Security With Ethereum's Versatility - Alexei Zamyatin 1:10:10

17 weeks پیش1:10:10

1:10:10

Bitcoin’s security and reliability as a store of value are undeniable. However, its liquidity remained untapped for too long due to a lack of trustless bridges and native smart contract capabilities. As BTC is only native to Bitcoin’s L1, any attempt to include it in DeFi relies on the trust assumptions of third party custodians that wrap it. Build On Bitcoin (BOB) aims to expand Bitcoin’s functionality by integrating it with Ethereum’s smart contract capabilities. BOB operates as an OP Stack L2 with a hybrid design incorporating ZKPs, Bitcoin staking, and Ethereum for data availability. By functioning as a rollup, BOB processes transactions off-chain and batches them for settlement on Bitcoin and Ethereum, significantly improving transaction speed and reducing costs compared to Bitcoin’s base layer. Topics covered in this episode: Alexei’s background Setbacks for Bitcoin DeFi Bitcoin bridges BitVM BOB operators and trust assumptions BOB architecture & Bitcoin staking Bitcoin LSTs The future of Bitcoin DeFi Episode links: Alexei Zamyatin on X Build on Bitcoin on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Brian Fabian Crain.…

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1
Puja Ohlhaver: Why Community Currencies Are Crucial for Governance in DeSoc 1:04:42

18 weeks پیش1:04:42

1:04:42

In the digital networked age, people’s attention often overlooks local problems in favour of global ones, which don’t necessarily impact them in their daily lives, or over which they don’t have a say due to the skewed Pareto distribution of power in modern day societies. Puja Ohlhaver, in her recent research paper ‘Community currencies’, proposes a dual-currency model that prices attention and influence in each community, with the ultimate goal of creating a Gaussian distribution of power, either locally, or globally through the dynamic interaction of multiple local communities. This model allows community members to stake their currency to earn non-transferable governance rights, creating a substrate for decentralised societal coordination that favours social innovation. Topics covered in this episode: Puja’s background Web3 research ‘Community currencies’ Pareto vs. Gaussian distributions Global vs. local power distributions The community currencies model Meritocracy vs. influence Quadratic funding Governance, bribery and the crisis of legitimacy Experimenting with community currencies Episode links: Puja Ohlhaver on X 'Community Currencies' Research Paper 'Decentralized Society' Research Paper Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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Nevermined: Payment System for the AI Agentic Economy - Don Gossen 1:04:38

18 weeks پیش1:04:38

1:04:38

Even though current LLM providers usually charge flat rates regardless if the subscriber is a ‘power user’ or not, as AI agents become the workhorses of the online economy, a dynamic AI-to-AI payments infrastructure would prove crucial for proper remuneration. Nevermined proposes a blockchain-agnostic, AI-agnostic credit system, that each builder can use to implement custom pricing strategies for their users. As the next trillion transactions will be mostly performed by AI agents, a universal payment system would help streamline integrations and economic interactions. Topics covered in this episode: Don’s background Integrating payment systems in the agentic economy Marketplaces vs. payment systems AI agentic economy Fixed vs. variable pricing strategies License tokenization Settlement and payment for AI agents Estimating price and avoiding overcharges Nevermined’s tech stack and integrations Value prop Nevermined metrics Episode links: Don Gossen on X Nevermined on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: one of the largest node operators worldwide, trusted by 175,000+ accounts across more than 60 networks, Chorus One combines institutional-grade security with the highest yields at - chorus.one This episode is hosted by Friederike Ernst.…

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1
Turtle Club: Helping Web3 Users Monetize Their On-Chain Activity - Esfandiar Lagevardi 1:09:25

20 weeks پیش1:09:25

1:09:25

As more and more protocols compete for marketshare, user acquisition represents one of the most important elements of the GTM strategy. Web3 projects, through their governance tokens, can incentivise users directly to participate in meaningful activities for each protocol, subsidising their revenue generation through vested upside in the project. Turtle Club built the first distribution protocol of Web3, helping its users maximise their rewards they get for meaningful on-chain activities that help bootstrap projects. Topics covered in this episode: Esfandiar’s background The evolution of DeFi Yield sustainability in DeFi DeFi vs. TradFi Quantifying risk Main blockers for DeFi adoption On-chain transparency or privacy? What is missing in DeFi? Genesis story of Turtle Club How Turtle Club users accrue rewards Episode links: Esfandiar Lagevardi on LinkedIn Turtle Club on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Brian Fabian Crain.…

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1
Story Protocol: Tokenizing Intelligence Into Programmable IP Assets - Jason Zhao 58:54

21 weeks پیش58:54

58:54

As online content becomes predominantly AI-driven, intellectual property (IP) rights should not be neglected as (human) creators will heavily rely on them. While the main use cases for blockchains revolve around financial applications, one could argue that our everyday lives constantly intersect IPs in different forms. Although the legal framework is abundant, proper recording, monetization and disputes are often a burden for independent creators. Story Protocol aims to create a decentralised framework for IP management, tokenizing it both through NFTs and fungible tokens, allowing creators to register fully programmable IP, that is also recognized and enforced through the traditional judiciary system. Using smart contracts and programmable metadata, Story Protocol ensures proper monetization for creators whenever their IP is used. Topics covered in this episode: Jason’s background Current IP pain points Tokenizing IP Story Protocol blockchain Preventing IP infringement Story Protocol validators Interoperability Onboarding traditional IP to Story Protocol Story Protocol’s legal framework Enforcing IP rights on Story Protocol Hiding or demonetizing on-chain IP Governance & disputes Roadmap Episode links: Jason Zhao on X Story Protocol on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Friederike Ernst.…

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Balancer: Custom AMMs and Liquidity Solutions - Fernando Martinelli 1:04:35

22 weeks پیش1:04:35

1:04:35

While AMMs (automated market makers) represent a DeFi innovation in themselves, research and experimentation have pushed the possibilities well beyond the limitations of the classic x*y=k constant product formula originally used by LPs. One of the main innovators in this field remains Balancer - from multi-token pools with different weights replicating TradFi indices, to dynamic ratios that can be changed under certain conditions preventing further imbalances, Balancer set in place user protection measures. With the recent release of Balancer V3, developers get more freedom to experiment with AMMs, introducing features such as hooks that enable limitless pool customisation, boosted pools that combine LP fees with yield farming from money markets, and many more. Topics covered in this episode: Balancer’s inception The evolution of AMMs Balancer vs. other AMM competitors Fungible vs. non-fungible liquidity Balancer v3 Boosted liquidity pools DevEx and hooks in Balancer v3 Preventing stablecoin depegs MEV mitigation & CoW AMM Scaling to L2s Gyroscope & QuantAMM Balancer’s B2C & B2B solutions Episode links: Fernando Martinelli on X Balancer on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Friederike Ernst.…

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1
Kiln: Democratising Value Creation in Digital Assets - Laszlo Szabo 59:58

23 weeks پیش59:58

59:58

Kiln operates as a staking-as-a-service platform, primarily focused on Ethereum, enabling users to stake assets programmatically, managing validators, rewards, and commissions through an API-first approach. In addition, it offers white-label solutions that allow institutional clients to integrate staking functionalities into their own offerings, with unified API for all assets and rewards, making it easier for businesses to provide staking services without developing the infrastructure themselves. With more than $13bn worth of assets secured, Kiln has proven its reliability, having no slashing events thus far. Moreover, Kiln widget offers a no-code experience for launching custom earn options, integrated with every major wallet and custodian. Topics covered in this episode: Laszlo’s background Founding Kiln Enterprise-grade validators and slashing DevOps & infrastructure maintenance ETH staking and custody Liquid staking and restaking The evolution of staking providers and requirements DeFi yield Institutional investors Kiln roadmap Episode links: Laszlo Szabo on X Kiln on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Friederike Ernst.…

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1
Babylon: Self-Custodial Bitcoin Native Staking & Bitcoin-Secured Networks - David Tse 49:43

24 weeks پیش49:43

49:43

Throughout the years, there were many attempts of tapping into Bitcoin’s liquidity and security, but almost all of them came with different caveats. Most notably, wrapped BTC (wBTC) depended on the wrapper contract security. However, the recent surge in research and development for native solutions has led to breakthroughs previously thought impossible. Babylon launched native BTC staking and plans to further expand this to secure other blockchains, in a model similar to that of mesh security. This would not only help secure other networks, but it would also unlock liquidity from the mother chain through liquid staking derivatives. Topics covered in this episode: David’s background The evolution of Babylon The Bitcoin Renaissance Technical challenges of implementing Bitcoin staking The OP_CAT upgrade Babylon’s Bitcoin staking & Bitcoin-secured networks Bridging liquidity & LSTs Securing multiple chains and slashing Babylon chain - aggregating Bitcoin-secured networks Could Bitcoin become a POS chain? Babylon upgradeability Episode links: David Tse on X Babylon on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Brian Fabian Crain & Sebastien Couture.…

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1
RedStone: The Oracle Pioneering the Future of DeFi - Marcin Kaźmierczak 1:04:40

25 weeks پیش1:04:40

1:04:40

The DeFi landscape has significantly evolved since 2018 when Chainlink was launched. Recent developments such as L2 rollups, liquid staking, restaking and the rise of BTC DeFi have created huge demand for more customizable, modular oracles that would be able to provide accurate data for countless use cases, crosschain. RedStone set out to do exactly that and are now securing over $6.6 bn worth of assets (1000+ assets), across more than 60 chains, without a single mispricing event. Topics covered in this episode: Marcin’s background Early oracle landscape RedStone’s technical architecture Network incentives Data aggregation module Node operator module Push vs. Pull oracles RedStone’s business model The role of RedStone token Pyth vs. RedStone Restaking Oracle extractable value Synergies between oracles and institutional investors Episode links: Marcin Kazmierczak on X RedStone on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Brian Fabian Crain.…

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1
Privado ID & Quark ID: On-Chain ZK-Powered Unified ID - Diego Fernandez & Evin McMullen 1:06:49

26 weeks پیش1:06:49

1:06:49

Traditional KYC and AML regulations have often forced companies to comply, without having the right tools to do so. Simply storing users’ personal information led to the creation of security honeypots which haven’t gone unnoticed by hackers. Web3 solutions like Privado ID aim to cryptographically prove certain traits from a user’s personal data, without disclosing it to the enquirer. This is usually made possible through zero knowledge proofs which allow users to store their personal data on their own device and only exchange verifiable credentials with trusted issuers. City of Buenos Aires has adopted a similar implementation through their Quark ID system, a digital trust framework that creates a new digital identity system, giving people control over their information. Topics covered in this episode: Evin’s background and founding Disco Polygon ID acquisition and blockchain agnostic decentralized IDs Diego’s background, from private to public practice Privado ID and its registry of reputation issuers Use cases, DevEx and UX KYC and regulations Buenos Aires digital ID system Real world applications of Quark ID UX frictions and solutions ZK verification Societal impact and adoption Ethical considerations around DIDs The role of blockchains in other real world applications Episode links: Evin McMullen on X Diego Fernandez on X Privado ID on X Quark ID on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Friederike Ernst.…

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1
Abundance: The First 1 Gigagas/second Stack for Sovereign Rollups - Hilmar Orth 1:09:00

27 weeks پیش1:09:00

1:09:00

One of the most limited blockchain resources is blockspace. From Bitcoin’s Blocksize Wars to Ethereum’s scaling roadmap, a common denominator seems to have emerged in the form of rollups. Advancements in zero knowledge proofs have enabled trustless bridges, which are a cornerstone to onboarding liquidity to any blockchain. Furthermore, Celestia’s modular approach to blockchain architecture and their recent commitment to gigabyte blocks of data availability marked the beginning of commoditization for rollups. Abundance is the first rollup-as-a-service platform that is able to scale to 1 gigagas/second throughput, finally bringing off-chain applications, on-chain. Topics covered in this episode: Gelato’s pivot to rollup-as-a-service platform Sovereign rollups Enshrined bridges and settlement proofs Abundance and 1 Gigagas/second rollups Modularity Security assumptions Sequencer (de)centralisation Social consensus Celestia’s DA layer bandwidth Ethereum native rollups Decentralisation and censorship-resistance Episode links: Hilmar Orth on X Gelato Network on X Abundance on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Friederike Ernst.…

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1
Monad: The EVM-Compatible 10,000 TPS L1 Blockchain - Keone Hon 1:10:54

28 weeks پیش1:10:54

1:10:54

The status quo for developers choosing an ecosystem for their blockchain usually revolves around trade-offs: do they go for Ethereum’s network effect, liquidity and decentralisation, or sacrifice some features in favour of a higher throughput. Monad aims to combine the best of both worlds, while not being limited by excessive hardware requirements. Monad built an EVM-compatible L1 from the ground up, completely rethinking execution and consensus, in order to achieve the infamous 10,000 TPS. This extreme scalability is made possible through Monad’s optimistic parallel execution which is asynchronous from consensus. The latter has also been optimized in order to achieve single-slot finality. Monad’s proprietary database architecture allows for states to be stored on SSDs instead of RAM, which ensures that consumer-grade hardware can run a Monad node, further increasing decentralisation. Topics covered in this episode: Keone’s background TradFi vs. DeFi and how Monad was founded EVM’s network effect vs. other VMs How Monad aims to improve EVM’s performance MonadDB MonadBFT - New consensus mechanism Asynchronous execution MEV and proposer-builder separation (PBS) Monad’s throughput Further scaling and limitations Alternatives & trade-offs DevEx Community & ecosystem development Episode links: Keone Hon on X Monad on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Brian Fabian Crain.…

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1
Succinct: Every Rollup Will Be a ZK Rollup! - Uma Roy 49:28

29 weeks پیش49:28

49:28

Polynomials are quintessential in machine learning for establishing relationships between outputs and inputs. However, there is also a field in cryptography which could not be made possible without polynomials - zero-knowledge technology. In zero-knowledge proof systems, computations are often represented as arithmetic circuits, and these circuits are translated into polynomials. This process is crucial for generating proofs that can demonstrate the correctness of computations without revealing the underlying data. The involved complexity explains the massive adoption hurdle for zk rollups compared to optimistic ones. Succinct aims to simplify the use of zero-knowledge proofs by providing a zkVM (SP1) that allows code written in languages like Rust to be proven in a privacy-preserving way. By doing so, it aims to lower the barrier to implementing zk-rollups and increase their adoption. Topics covered in this episode: Uma’s background and her interest in zero knowledge tech How Succinct’s story began ZK light clients ZK circuits SP1 and the RISC-V instruction set The prover network Use cases ZK rollups and commoditizing ZKPs Incentivizing provers Succinct’s business model Supported blockchain applications Bottlenecks in ZK adoption Succinct metrics SP1’s competitive advantage and future roadmap The real world impact of verifiability Episode links: Uma Roy on X Succinct on X Sponsors: Gnosis: Gnosis builds decentralized infrastructure for the Ethereum ecosystem, since 2015. This year marks the launch of Gnosis Pay— the world's first Decentralized Payment Network. Get started today at - gnosis.io Chorus One: Chorus One is one of the largest node operators worldwide, supporting more than 100,000 delegators, across 45 networks. The recently launched OPUS allows staking up to 8,000 ETH in a single transaction. Enjoy the highest yields and institutional grade security at - chorus.one This episode is hosted by Friederike Ernst.…

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Epicenter - Learn about Crypto, Blockchain, Ethereum, Bitcoin and Distributed Technologies « » Paul Kohlhaas & Tyler Golato: VitaDAO – The Collective Funding Longevity Research

Paul Kohlhaas & Tyler Golato: VitaDAO – The Collective Funding Longevity Research

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Paul Kohlhaas & Tyler Golato: VitaDAO – The Collective Funding Longevity Research