The Big Picture of Small Things: Nanotoxicology

Adverse Reactions

Nanoparticles are manmade fibers, particulates, and other objects that are so small that when inhaled, they can escape the lungs and enter other body systems. Timothy Nurkiewicz, West Virginia University, studies the effects of these and other particulars. He discusses his inhalation and nanotoxicology research, as well as work with the National Guard on developing facemasks to protect against airborne diseases, with co-hosts Anne Chappelle and David Faulkner.
About the Guest
Timothy R. Nurkiewicz, PhD, is the E.J. Van Liere Medicine Professor and Chair of the Department of Physiology and Pharmacology at the West Virginia University (WVU) School of Medicine. He is also the Director of the WVU Inhalation Facilities and Center for Inhalation Toxicology (iTOX) and has been a guest researcher with the National Institute for Occupational Safety and Health since 2008.

Dr. Nurkiewicz’s research is in the fields of microvascular physiology and toxicology, with specific focus on pulmonary exposure to particulate matter and engineered nanomaterials. His research program pioneered novel investigations in the field of maternal nanomaterial exposures and fetal microvascular ramifications. Through iTOX, his lab and team are able to replicate the atmospheres that humans are exposed to in order to advance understanding of their acute and chronic toxicities.
Dr. Nurkiewicz earned a BS in exercise and sport science from Pennsylvania State University, a MS in exercise physiology from WVU, and a PhD in physiology from WVU. He completed postdocs at Texas A&M University and WVU. Currently, Dr. Nurkiewicz serves as an Associate Editor for Frontiers—Vascular Physiology and Particle and Fibre Toxicology and is a founding member and Past President of the SOT Cardiovascular Toxicology Specialty Section.

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1. Introduction to the Episode (00:00:00)

2. What Do You Do? (00:01:12)

3. Microcirculation Is the Most Important Tissue in the Body? (00:02:43)

4. The Developmental Origins of Health and Disease (00:04:03)

5. Breaking Down the Three Flavors of Particulate Matter and Nanoparticles (00:07:31)

6. The Toxicological Effects of Nanomaterials (00:11:42)

7. Aerosol Engineers + Toxicology (00:15:31)

8. From Studying Physiology to Expertise in Toxicology (00:17:19)

9. The Health Effects of Mining on Non-miners (00:19:35)

10. Creating Face Masks for the National Guard (00:23:33)

11. If You Weren't a Scientist... (00:27:25)

12. Episode Credits (00:28:26)